CellNetix pathologist, Dr. Jey-Hsin Chen, presented a poster titled “Improved Interobserver Agreement in Keratin Immunohistochemistry-Assisted Diagnosis of Peritoneal Membrane Invasion by Colorectal Adenocarcinoma” at the United States & Canadian Academy of Pathology (USCAP) 2020 Annual Meeting on February 29-March 5 in Los Angeles, CA. The poster was authored by CellNetix pathologists Drs. Chen, Rajen Goyal, Lisa Thomassen, and others.
pT3 colorectal adenocarcinoma is clinicopathologically heterogeneous and deeply invasive tumors, such as those that invade the peritoneal membrane, may behave more aggressively than shallower tumors. Recognizing tumors that invade the peritoneal membrane can be diagnostically challenging and time-consuming, however, but the diagnosis may be enhanced with the use of an ancillary keratin immunostain. To study this, six experienced pathologists were asked to analyze 50 cases of pT3 colorectal adenocarcinoma. The study found that incorporating a keratin immunostain significantly improved the diagnostic agreement, performance, and confidence among practicing pathologists in segregating “deeply invasive” from “shallow” pT3 colorectal adenocarcinomas, which in turn may help guide better treatment of these patients.
Pictured from L to R: Drs. Jey-Hsin Chen, Lisa Thomassen, Rajen Goyal