ZAP-70

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

This is a send out test.

Identifies: ZAP-70, a cytoplasmic protein ubiquitously expressed in T cells and NK cells, and in neoplasms derived from these cells. Most normal B cells do not express ZAP-70, but it is expressed in a variety of B cell non-Hodgkin lymphomas. Importantly, expression of ZAP-70 in chronic lymphocytic leukemia/small lymphocytic lymphoma strongly correlates with a lack in immunoglobulin gene mutation, and has been associated with an adverse prognosis.