PD-L1 NonLung

Synonyms

PD-L1, 22C3

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code PD-L1 NonLung
  • Schedule Monday - Friday
  • Turn Around Time Within 2-3 business days of receipt
  • Disease State Cervical Cancer, Classical Hodgkin Lymphoma, Gastric Cancer, Hepatocellular Carcinoma, Melanoma
  • Methodology IHC

Organs

Bladder, Cervix, Colon, Gastric, Liver, Lymph nodes

Specimen Requirements

Formalin fixed tissue or FFPE prepared tissue blocks

Clinical Significance

Many tumor cells are able to upregulate the expression of PD-L1 (programmed death ligand 1) as a mechanism to evade the body's natural immune response. Activated T-cells recognize the PD-L1 markers on the malignant cell, similar to the normal cell, rendering the T-cell inactive. Anti-PD-1 therapies can be used then to block the PD-1 receptor and so boost the effectiveness of cytotoxic T cells.

Cause for Rejection

Fewer than 100 intact malignant cells

Vendor

Agilent