PD-L1 Lung

Synonyms

PD-L1, 22C3

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code PD-L1 Lung
  • Schedule Monday - Friday
  • Turn Around Time Within 2-3 business days of receipt
  • Disease State Non Small Cell Lung Carcinoma (NSCLC)
  • Methodology IHC

Organs

Lung

Specimen Requirements

Formalin fixed tissue or FFPE prepared tissue blocks

Clinical Significance

Many tumor cells are able to upregulate the expression of PD-L1 (programmed death ligand 1) as a mechanism to evade the body's natural immune response. Activated T-cells recognize the PD-L1 markers on the malignant cell, similar to the normal cell, rendering the T-cell inactive. Anti-PD-1 therapies can be used then to block the PD-1 receptor and so boost the effectiveness of cytotoxic T cells.

Cause for Rejection

Fewer than 100 intact malignant cells

Vendor

Agilent