MYD88_265P by PCR
Myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); MYD88_L265P; Lymphoplasmacytic Lymphoma; Waldenström Macroglobulinemia
- Tech Only CPT 81305
- Tech Pro CPT
- PowerPath Code MYD88
- Schedule Wednesday
- Turn Around Time 7-10 Days
- Disease State Lymphoplasmacytic Lymphoma, Waldenstrom's macroglobulinemia
- Methodology Real-time Polymerase Chain Reaction (qPCR)-based analysis of the L265P mutation in the MYD88 gene
Organs
Specimen Requirements
Minimum of 1 mL whole blood in a purple (EDTA) or pink top tube (EDTA); minimum of 1 mL of bone marrow aspirate in a purple, pink, or green (heparin) top tube.
Clinical Significance
Activating mutations of MYD88, particularly the Leu265Pro mutation, are frequently identified in Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia patients and less frequently in marginal zone lymphoma patients. The same mutation is also found in chronic lymphocytic leukemia and the Activated B-cell type Diffuse Large B-cell Lymphomas.
Required Patient Info
Copy of the referring client's requisition form to accompany specimen.
Storage and Transportation
Refrigerated: 5 days; ambient (room temperature): 3 days; specimen must be received by laboratory within 7 days of collection.
Cause for Rejection
Frozen specimen; clotted or grossly hemolyzed specimens; serum; specimens without 2 patient identifiers; serum or plasma, aliquots (previously open containers); specimen that were received >7 days after collection.
Retention
one week - whole blood. DNA - 2 years. FFPE tissue blocks - 10 years
Comments
Copy of the referring client's requisition form to accompany specimen.
Results of this test must always be interpreted in the context of relevant clinical and pathological data, and should not be used alone for a diagnosis of malignancy.