MDS FISH Panel

Minimum 1mL of bone marrow aspirate or peripheral blood in green top sodium heparin (preferred) or purple top EDTA (acceptable). Contact FISH lab for fresh tissue or other fluid.

The targeted gene gains or losses are the common chromosome abnormalities seen in patients with myelodysplastic syndromes (MDS) or other myeloid malignancies.

In conjunction with morphologic, cytogenetic, and molecular studies, the targeted chromosome abnormalities in this FISH panel play a key role in the evaluation of patients with MDS, and can be used in prognosis stratification, drug response, and disease monitoring.

MDS FISH Panel includes the following probes:
Del(5q); 5p15.3/5q31.2
Monosomy 7/del(7q); CEP7/7q31.2
Trisomy 8; CEP8
TP53 deletion; 17p13/CEP17
Del(20q); 20q12/20q13.1

Room temperature, express mail if not on courier service

Improperly labelled specimens will be rejected (must have two patient identifiers); frozen blood or bone marrow; FFPE blocks. PB and BM specimens collected in containers other than EDTA and NaHep

5 days for original sample; 1 month for fixed cell pellets

Clinical indication and specimen source is required for the assay.