Langerin

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Langerin is a type II transmembrane glycoprotein of the lectin family, which is associated with the formation of Birbeck granules in Langerhans cells. It is a highly sensitive and fairly specific marker for Langerhans cells and Langerhans cell neoplasms (e.g., Langerhans cell histiocytosis), a helpful adjunt to S100 protein and CD1a in this respect.