High-Risk Human Papillomavirus
HPV, hrHPV
- Tech Only CPT 87624
- Tech Pro CPT
- PowerPath Code HPV HR Cobas
- Schedule Monday - Friday
- Turn Around Time Within 3 days of receipt
- Disease State Cervical Cancer, Cervical Dysplasia, Human Papillomavirus
- Methodology PCR
Organs
Specimen Requirements
-ThinPrep vial containing a cervical or anal specimen collected in PreservCyt (clinician-collected). Minimum volume 1mL.
-ThinPrep vial containing a vaginal specimen collected in PreservCyt (self-collected by patient in a clinical setting).
Clinical Significance
Persistent infection with Human Papillomavirus (HPV) is the principal cause of cervical cancer and its precursor cervical intraepithelial neoplasia.
Tests for High-Risk HPV subtypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 without differentiation.
Required Patient Info
2 patient identifiers
Storage and Transportation
15°C - 30°C. Do not freeze.
Cause for Rejection
Improper collection medium (i.e., not in a ThinPrep vial), improper or inadequate patient identification, frozen specimens.
Retention
4 weeks from processing
Comments
Can be paired with HPV Genotyping 16 & 18. Detailed algorithms for the use of high-risk HPV DNA testing in various clinical scenarios is available at: http://www.asccp.org/Guidelines/Screening-Guidelines
Can be performed as:
HPV Regardless - Tests for HPV alongside cytology
HPV Reflex - Tests for HPV following an Atypical Squamous Cells of Undetermined Significance (ASCUS) cytology diagnosis
HPV Only - Tests for HPV without cytology. Cytology can be performed reflexively based on HPV results only on clinician-collected cervical or anal specimens. Reflexive cytology cannot be performed on self-collected vaginal specimens.