Glutamine Synthetase

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Classification of well-differentiated hepatocellular neoplasms: Diffusely expressed in focal nodular hyperplasia and subset of β-catenin mutated hepatocellular adenomas. Perivenular expression in non-neoplastic liver. Best used as part of a panel [serum amyloid A (SAA), c-reactive protein (CRP), β-catenin, liver fatty acid binding protein (LFABP), glutamine synthetase].