CK5

Synonyms

CK5-XM26 Cytokeratin 5

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Disease State Adenocarcinoma, Carcinomas of Unknown Primary, Mesothelioma vs. Adenocarcinoma, Non Small Cell Lung Carcinoma (NSCLC), Spindle Cell Tumors / Sarcoma Subtyping
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Identifies squamous and transitional cell epithelia, mesothelium, ductal epithelium and their corresponding carcinomas. In complex epithelia such as normal prostate glands, the basal cells in most cases express CK5. CK5 expression can also be seen in some nonsquamous carcinomas, e.g., pancreatic adenocarcinoma.