CD30

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

CD30 is expressed by the Reed-Sternberg cells and its variants in a great majority of classical Hodgkin lymphoma. It is also expressed by anaplastic large cell lymphoma, primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and a subset of diffuse large B-cell lymphoma. CD30 is positive in embryonal carcinoma and is a useful marker in germ cell tumors. Note that CD30 is also expressed by a significant subset of activated B- and T-cells (non-neoplastic).