- Tech Only CPT
- Tech Pro CPT 81206, 81207
- PowerPath Code BCR-ABL Screen
- Schedule Monday - Friday (Variable)
- Turn Around Time 4-7 days
- Disease State Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML)
- Methodology Reverse-Transcriptase and real-time (RT-qPCR) polymerase chain reaction to measure the quantity of BCR-ABL1 fusion transcript p190 (e1a2) and p210 (b2a2/ b3a2)
Minimum of 1 mL whole blood in a purple (EDTA) or pink top tube (EDTA);
Minimum of 1 mL of bone marrow aspirate in a purple, pink, or green (heparin) top tube.
Presence of the BCR-ABL1 fusion transcript is seen in a majority of patients with CML, and in a subset of patients of B-ALL. Quantitative monitoring of the BCR-ABL1 transcript can act as a diagnostic tool and provide guidance during therapy.
Monitoring tyrosine kinase therapy in patients with CML with known e13a2 or e14a2 fusion transcripts. The transcript level for the major breakpoint (p210)is reported as a percentage of BCR-ABL1:ABL1 ratio by using the International Scale (IS). BCR-ABL1 p190: Monitoring therapy in patients with CML or other BCR-ABL1 positive neoplasms with known ela2 fusion transcript. The transcript level for the minor breakpoint (p190) is reported as the NCN% ratio of BCR-ABL1 to ABL1.
Required Patient Info
If patient has had BCR ABL testing previously please provide results, date and performing laboratory information.
Storage and Transportation
Refrigerated; specimens must be delivered to the lab within 72-hours of collection
Cause for Rejection
Frozen specimen; clotted or grossly hemolyzed specimens; serum; specimens without 2 patient identifiers; serum or plasma, aliquots (previously open containers); bone marrow cores (fresh or FFPE); collection date >72-hours from receipt and RNA has shown signs of significant degradation.
One week - whole blood or bone marrow; RNA and data - 2 years
This test was developed and its performance characteristics determined by CellNetix Labs LLC. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. CellNetix is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.