What is the SymGene Myeloid Panel?
The SymGene™ Myeloid panel is used to screen recurrent, acquired mutations in 37 genes that play key roles in development of myeloid stem cell neoplasms. The mutation status of these genes confirms diagnosis, provides further classification, predicts prognostic values, and directs therapeutic targets and treatment decisions.
Who Should Have This Test Run?
Individuals with known or suspected hematologic neoplasms, including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), chronic myelomonocytic leukemia (CMML), and Chronic Myeloid Leukemia (CML), at the time of time of diagnosis and downstream follow-ups.
Test Details
- Assesses of hotspot mutations, such as substitutions, insertions, and deletions, in the coding regions of the 37-gene on the panel.
- For AML patients, FLT3/NPM1 PCR with concurrent order of NGS_Myeloid panel is the most effective approach to achieve a fast, accurate, and comprehensive testing algorithm.
- For suspected MPN patients, JAK2_V617F, CALR_ex9 indel, MPL PCR reflexed to NGS_Myeloid panel would be most efficient and comprehensive approach.
- This test is intended to evaluate for somatic mutations within the blood or bone marrow samples. It is unable to differentiate the somatic or germline origin for the detected variants.
What Genes Are Included in the Myeloid Panel?
| ABL1 | ANKRD26 | ASXL1 | BCOR | BRAF | CALR | CBL |
| CEBPA | CSF3R | DDX41 | DNMT3A | ETNK1 | ETV6 | EZH2 |
| FLT3 | GATA1 | GATA2 | IDH1 | IDH2 | JAK2(exon12-16) | KIT |
| KRAS | MPL | NPM1 | NRAS | PHF6 | PTPN11 | RUNX1 |
| SETBP1 | SF3B1 | SRSF2 | STAG2 | TET2 | TP53 | U2AF1 |
| WT1 | ZRSR2 |
Order SymGene
Healthcare providers have several options for ordering SymGene for their patients including LabDOX, fax, and phone. Healthcare providers must first complete a test requisition form to start the process. Turn around time is 8-12 days from the time a specimen is received.
