The SymGene79™ cancer panel includes carefully selected oncogenes and tumor suppressor genes with compelling clinical and biological evidences as biomarkers to predict responses to targeted therapies.
- Most of which have received FDA approval as standard treatment for certain tumor types.
- Genetic profiling of these genes is useful for assessing prognosis and guiding treatment of individuals with advanced cancer who have exhausted standard treatment options.
- The panel can also be used to help determine clinical trial eligibility for patients with alterations in genes not amenable to current FDA-Approved targeted therapies.
Test Description
- Genes have been selected based on the most recent literature review.
- Designed for tumor profiling of primary or metastatic major solid tumor types.
- Assessing the entire coding exons of each gene for substitutions, insertions and deletions less than 50 bp, copy number variants (gene amplifications or homozygous loss).
Process & Reporting
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- FFPE blocks are preferred but cytology smears are acceptable.
- All information on the report is individually evaluated by a geneticist and molecular pathologist.
- Genomic data is correlated with the morphology by our expert pathologists before reporting.
AKT1 |
ALK |
APC |
ARAF |
ATM |
BCL2L11 |
BRAF |
BRCA1 |
BRCA2 |
BTK |
CCND1 |
CDK4 |
CDK6 |
CDKN2A |
CSF1R |
CTNNB1 |
DDR2 |
EGFR |
EPHA2 |
ERBB2 |
ERBB4 |
ESR1 |
FGFR1 |
FGFR2 |
FGFR3 |
FLT1 (VEGFR1) |
FLT3 |
FLT4 |
FOXL2 |
FYN |
GLI2 |
GNA11 |
GNAQ |
GNAS |
HDAC2 |
HRAS |
IGF1R |
JAK2 |
JAK3 |
KDR (VEGFR2) |
KIT |
KRAS |
LCK |
LYN |
MAP2K1 (MEK1) |
MAP2K2 (MEK2) |
MDM2 |
MET |
MLH1 |
MSH2 |
MSH6 |
MST1R (RON) |
MTOR |
NOTCH1 |
NRAS |
NTRK2 |
PDGFRA |
PDGFRB |
PIK3CA |
PMS2 |
POLD1 |
POLE |
PTCH1 |
PTEN |
RAF1 |
RB1 |
RET |
ROS1 |
SMAD4 |
SMO |
SRC |
STK11 |
TEK |
TERT |
TP53 |
TSC1 |
TSC2 |
VHL |
YES1 |
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