Danbin Xu, MD, PhD
Chief Scientific Officer
Molecular pathology is the study of genetics and genomics in a disease state. At CellNetix, we utilize sensitive molecular tools that help confirm ambiguous diagnoses, determine overall prognostic outlook, and guide therapeutic decisions. Molecular techniques can also assist in predicting effectiveness of some important medications, as well as identifying specific targets unique to individual tumors for new therapeutic modalities.
NGS is a high throughput sequencing technology used to detect unique genetic alterations in tumors cells. The massively parallel nature of this method significantly increases sequencing sensitivity and sequencing capacity when compared to the traditional Sanger sequencing. This method is commonly used to screen all actionable mutations in a panel of genes relevant to a given cancer type. Learn more about the SymGene panels below:
PCR is a fundamental molecular technique to rapidly amplify specific DNA segments from a small amount of sample input. This method is used to detect common targeted mutations in each gene, and is particularly useful in cases where rapid turnaround time is paramount.
FISH is a cytogenetic technique used in identification and localization of specific gene sequences on chromosomes. The beauty of FISH analysis is the ability to detect gene deletion, amplification, and/or structural rearrangements at a single cell level in tissue or blood.
If you are not set up with an electronic interface, please contact your local representative or complete a Molecular Oncology or Hematopathology requisition form and fax it to 206-215-5935 or 866-721-9696.