CD25 (IL-2Rß)

Synonyms

Alternative test to TRAP

  • Tech Only CPT
  • Tech Pro CPT 88342.TC, 88342.26
  • PowerPath Code
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Disease State Anaplastic Large Cell Lymphoma (Systemic or Cutaneous), Hairy Cell Leukemia, Mastocytosis
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

CD25 (IL-2Rß) is a cell surface-associated protein that is the receptor for interleukin-2. CD25 is expressed on a significant subset of activated T cells, and tends to be strongly expressed on the neoplastic T cells of adult T cell leukemia/lymphoma and anaplastic large cell lymphoma. CD25 is also coexpressed on a subset of B cell neoplasms, most notably hairy cell leukemia.