Brachyury

  • Tech Only CPT
  • Tech Pro CPT 88342
  • PowerPath Code brachy
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Brachyury is a nuclear transcription factor encoded by T, a member of the T-box gene family. It is crucial in the posterior mesoderm formation and in notochord development during embryogenesis. Thought to be an indicator of notochordal differentiation, brachyury is found to be a sensitive and specific maker for chordoma, and is extremely helpful in distinguishing chordoma from other histologic mimickers, including chondrosarcoma, metastatic mucinous / signet ring cell carcinoma, clear cell renal cell carcinoma, and etc.

Vendor

Santa Cruz Biotechnology, Inc.