ALK protein (p80)

  • Tech Only CPT
  • Tech Pro CPT 88342.TC, 88342.26
  • PowerPath Code ALK
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Identifies anaplastic large cell lymphoma and other T cell lymphomas. ALK is a protein overexpressed as a consequence of the (2;5) translocation that is found in anaplastic large cell lymphoma (ALCL). Expression of ALK is also seen in embryonal carcinomas and in a subset of inflammatory myofibroblastic tumors.Subcellular Localization: Nuclear and cytoplasmic