Hepatocyte nuclear factor-1β

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Hepatocyte nuclear factor-1β is found to be overexpressed in ovarian clear cell carcinoma by gene expression profiling, and it is later confirmed that HNF-1β is up-regulated at both mRNA and protein levels. HNF-1β has thus become a sensitive and specific marker for ovarian clear cell carcinoma, and is helpful in its distinction from other ovarian surface carcinomas with clear cell change, such as high-grade serous and endometrioid carcinomas.