Caldesmon

Synonyms

Heavy-caldesmon

  • Tech Only CPT 88342.TC
  • Tech Pro CPT 88342.TC, 88342.26
  • PowerPath Code CALD
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle tissue contraction. The heavy-caldesmon is predominantly expressed in smooth muscle tissue and can be used as a smooth muscle marker. It is helpful in the distinction of smooth muscle neoplasm (positive) from myofibroblastic proliferation, such as nodular fasciitis (generally negative). It is also generally negative in endometrial stromal tumors.

Vendor

Dako