BOB.1

Synonyms

B-cell Oct-binding protein 1; OBF.1

  • Tech Only CPT
  • Tech Pro CPT 88342
  • PowerPath Code bob1
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Disease State B Cell Non-Hodgkin Lymphoma (not otherwise classified), Classical Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Bob.1, a nuclear transcription factor, is expressed in normal B-lymphocytes throughout maturation, from immature forms to plasma cells. It is a useful B-cell marker, and is expressed in various B-cell lymphomas, including lymphocyte predominant Hodgkin lymphoma. The expression of Bob.1 in LP Hodgkin lymphoma may be useful in its distinction from classical Hodgkin lymphoma, where the expression of Oct-2 or Bob.1 or both may be lost.

Vendor

Cell Marque