p16

Synonyms

p16-INK4a

  • Tech Only CPT 88342.TC
  • Tech Pro CPT
  • PowerPath Code P16
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

Protein expressed by p16-INK4a tumor suppressor gene important in cell cycle regulation. Overexpression is associated with viral oncogenes E6 and E7 and therefore a surrogate marker for high-risk types of human papilloma virus (HPV) in cervical, vulvar, vaginal, and anal mucosa. Overexpression in squamous cell carcinomas of the head and neck can serve as a prognostic marker.

Vendor

Ventana