STAT6

  • Tech Only CPT
  • Tech Pro CPT
  • PowerPath Code stat6
  • Schedule Monday to Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained slide (charged slide) for each test requested plus 3-4 additional unstaind slides cut at 4 microns

Diagnostic Utility

STAT6 is a member of the signal transducers and activators of transcription (STAT) family that normally is located in the cytoplasm in an inactive form and migrates to the nucleus to bind to DNA targets upon cytokines (IL-4 and IL-3) stimulation and subsequent phosphoration. Recnt studies have shown a recurrent NAB2-STAT6 intrachromosomal fusion on chromosome12q13 in a great majority of solitary fibrous tumor. Nuclear STAT6 immunoreactivity has then been shown to be an excellent surrogate for the NAB2-STAT6 gene fusion, and is a highly sensitive and specific marker for SFTs from various anatomical sites, including the cranial / meningeal hemangiopericytoma. A small percentage of dedifferentiated liposarcoma has also been noted to show nuclear staining, though frequently weak, for STAT6, likely as a result of the close proximity of STAT6 to MDM2 gene at 12q15 and its inclusion in the amplicons in some of the tumors.

Vendor

Abcam