Her2

Synonyms

HER2 /neu; c-erbB-2

  • Tech Only CPT 88342.TC
  • Tech Pro CPT
  • PowerPath Code HER2-IA (Breast), HER2 G (Gastric), HER2-Colon
  • Schedule Monday - Friday
  • Turn Around Time Within 1-2 business days of receipt
  • Disease State Breast Cancer, Colon cancer, Gastric Cancer
  • Methodology IHC

Specimen Requirements

Formalin-fixed, paraffin embedded tissue block or cell block, or 1 unstained charged slide for each test requested plus 3-4 additional unstained slides cut at 4 microns. Adequate space on each slide for control tissue is required.

Diagnostic Utility

HER2 (c-erbB-2) oncoprotein is a 185 kDa transmembrane glycoprotein (tyrosine kinase), which is overexpressed (most commonly through gene amplification) in up to 18-20% of breast carcinomas, 24-35% of gastroesophageal junction carcinomas, and 9-18% of gastric carcinomas. It is a prognostic and predictive marker, and is tested in all invasive breast carcinoma and a subset of gastric and gastroesophageal junction carcinomas for determining the use of trastuzumab (Herceptin) and other HER2-targeted therapies.

Vendor

Ventana